Jason J Luke Selected Research

ASP9853

3/2016

ASP9853, an inhibitor of inducible nitric oxide synthase dimerization, in combination with docetaxel: preclinical investigation and a Phase I study in advanced solid tumors.

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Jason J Luke Research Topics

Disease

97	Neoplasms (Cancer) 04/2024 - 04/2012
78	Melanoma (Melanoma, Malignant) 04/2024 - 01/2012
12	Neoplasm Metastasis (Metastasis) 03/2024 - 10/2013
11	Uveal melanoma 10/2023 - 10/2013
6	Disease Progression 01/2023 - 01/2016
5	Bites and Stings (Sting) 01/2023 - 01/2019
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 02/2015
4	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 04/2012
4	Renal Cell Carcinoma (Grawitz Tumor) 01/2020 - 02/2015
3	Fatigue 03/2024 - 11/2015
3	Fever (Fevers) 01/2022 - 01/2014
3	Lung Neoplasms (Lung Cancer) 01/2018 - 03/2014
2	Brain Neoplasms (Brain Tumor) 10/2023 - 10/2022
2	Hypoxia (Hypoxemia) 01/2023 - 01/2022
2	Pneumonia (Pneumonitis) 11/2022 - 01/2022
2	Autoimmune Hepatitis 11/2022 - 01/2014
2	Hypertension (High Blood Pressure) 11/2022 - 11/2015
2	Diarrhea 01/2022 - 01/2017
2	Inflammation (Inflammations) 01/2022 - 05/2021
2	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 01/2020
2	Ascites 01/2020 - 01/2018
2	Urinary Bladder Neoplasms (Bladder Cancer) 01/2019 - 01/2018
2	Testicular Neoplasms (Testicular Cancer) 11/2016 - 06/2013
1	Prostatic Neoplasms (Prostate Cancer) 04/2024
1	Colorectal Neoplasms (Colorectal Cancer) 03/2024
1	Squamous Cell Carcinoma of Head and Neck 03/2024
1	Dermatitis 03/2024
1	Skin Neoplasms (Skin Cancer) 01/2024

Drug/Important Bio-Agent (IBA)

36	Immune Checkpoint InhibitorsIBA 04/2024 - 01/2014
28	pembrolizumabIBA 03/2024 - 02/2015
27	IpilimumabIBA 01/2024 - 04/2013
14	Biomarkers (Surrogate Marker)IBA 04/2024 - 11/2016
14	NivolumabIBA 03/2024 - 02/2015
10	InterferonsIBA 02/2024 - 01/2018
8	Proteins (Proteins, Gene)FDA Link 01/2023 - 10/2013
7	CytokinesIBA 01/2023 - 01/2018
7	AntibodiesIBA 12/2020 - 01/2014
7	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020 - 06/2013
5	trametinibIBA 01/2023 - 06/2013
5	AntigensIBA 10/2022 - 06/2013
5	DNA (Deoxyribonucleic Acid)IBA 05/2021 - 03/2014
5	CateninsIBA 10/2020 - 05/2019
5	VemurafenibIBA 11/2019 - 01/2012
4	Monoclonal AntibodiesIBA 03/2024 - 01/2014
4	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2024 - 10/2022
4	Programmed Cell Death 1 ReceptorIBA 10/2023 - 01/2019
4	EnzymesIBA 01/2023 - 01/2015
4	ChemokinesIBA 01/2023 - 01/2019
4	epacadostatIBA 01/2023 - 11/2018
4	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2022 - 02/2015
4	dabrafenibIBA 01/2022 - 06/2013
3	Adenosine (Adenocard)FDA LinkGeneric 01/2022 - 01/2020
3	Gemcitabine FDA Link 01/2022 - 11/2015
3	VaccinesIBA 12/2020 - 01/2016
3	LigandsIBA 11/2019 - 11/2016
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 04/2024 - 01/2019
2	Protein Isoforms (Isoforms)IBA 04/2024 - 01/2018
2	urelumabIBA 03/2024 - 10/2021
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 02/2024 - 09/2019
2	Interleukin-8 (Interleukin 8)IBA 02/2024 - 01/2023
2	B7-H1 AntigenIBA 10/2023 - 01/2019
2	RNA (Ribonucleic Acid)IBA 08/2023 - 01/2022
2	Blood Proteins (Serum Proteins)IBA 01/2023 - 01/2022
2	atezolizumabIBA 01/2023 - 01/2019
2	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2023 - 11/2018
2	Indicators and Reagents (Reagents)IBA 11/2022 - 01/2017
2	tebentafuspIBA 11/2022 - 10/2022
2	Mitogen-Activated Protein KinasesIBA 10/2022 - 01/2014
2	Toll-Like Receptor 9IBA 12/2021 - 01/2020
2	Interferon Type IIBA 05/2021 - 01/2019
2	Immunoconjugates (Immunoconjugate)IBA 01/2021 - 01/2019
2	Interleukin-2 (IL2)IBA 01/2021 - 04/2013
2	Transcription Factors (Transcription Factor)IBA 10/2020 - 01/2018
2	Hormones (Hormone)IBA 10/2020 - 02/2015
2	Dacarbazine (DIC)FDA LinkGeneric 01/2020 - 04/2013
2	Valine (L-Valine)FDA Link 01/2019 - 01/2012
2	Codon (Codons)IBA 01/2019 - 01/2012
2	Blocking AntibodiesIBA 01/2018 - 01/2016
2	Proto-Oncogene Proteins B-rafIBA 01/2018 - 08/2014
2	Docetaxel (Taxotere)FDA Link 03/2016 - 11/2015
1	Midazolam (Versed)FDA LinkGeneric 04/2024
1	Cytochrome P-450 CYP3AIBA 04/2024
1	capivasertibIBA 04/2024
1	Cetuximab (Erbitux)FDA Link 03/2024
1	C-Reactive ProteinIBA 02/2024
1	Tacrolimus (Prograf)FDA LinkGeneric 01/2024
1	prednylidene (Pred)IBA 01/2024
1	Prednisone (Sone)FDA LinkGeneric 01/2024
1	Messenger RNA (mRNA)IBA 01/2024
1	margetuximabIBA 11/2023
1	HLA-A Antigens (HLA-A)IBA 10/2023
1	p38 Mitogen-Activated Protein KinasesIBA 08/2023
1	NucleotidesIBA 01/2023

Therapy/Procedure

62	Therapeutics 04/2024 - 01/2012
56	Immunotherapy 04/2024 - 05/2013
9	Drug Therapy (Chemotherapy) 10/2023 - 04/2012
6	Radiotherapy 11/2023 - 01/2018
2	Injections 10/2023 - 01/2023
2	Precision Medicine 01/2023 - 01/2021
1	Oncolytic Virotherapy 10/2023